- Chelsea will travel to St, Mary's to take on Southampton in a crunch Premier League tie
- Thomas Tuchel will be chasing his fifth consecutive win in the league and continue his unbeaten run as manager
- Tammy Abraham and Thiago Silva could be rested for their last 16 Champions League tie against Atletico Madrid
Thomas Tuchel remains unbeaten since his arrival at Stamford Bridge at he faces a stern test against the Saints.
A win would see the Blues rise to fourth position on the league standings and Tuchel is taking no chances in selecting a strong squad for the contest.
Tammy Abraham's injury against Newcastle could pave way for Olivier Giroud as Timo Werner and Mason Mount could complete the front three following a calf injury to Christian Pulisic.
In the middle of the park, Jorginho and Mateo Kovacic could be given the opportunities to start while N'Golo Kante will complete the midfield trio.
At the heart of the defence, Andreas Christensen could replace Thiago Silva who will be reserved for their upcoming Champions League contest against Atletico Madrid.
Antonio Rudiger and captain Cesare Azpilicueta will complete the back three to act as cover-up for the wing-backs.
Callum Hudson-Odoi and Marcos Alonso are likely to feature as the wing-backs once again while Reece James and Ben Chilwell will be potentially saved for the midweek clash with Atletico.
Kepa Arrizabalaga was handed a rare start in the win over Newcastle but Edouard Mendy should return to the squad to retain his number one role.
Meanwhile, Legit.ng had earlier reported that Chelsea gaffer Thomas Tuchel has explained that the Stamford Bridge landlords have not made any decision on the future of French striker Olivier Giroud who is approaching the last months of his contract at the London side.
So far this season in the Premier League, Olivier Giroud has scored 10 goals for Chelsea and the Frenchman is wanted by many clubs in Europe.
Since becoming the coach of the Blues, Thomas Tuchel been able to get some impressive result with the Premier League giants.
Akan Anwankwo is a sports editor with Legit.ng and has 7 years of field and office experience. He graduated from the University of Lagos in 2014 with a Bachelors degree in English and Literature Studies. Akan intends to educate, inform and make readers passionate about sports. Learn more about him on his Twitter handle: @ anwankwo_akan