Group A, B, C, and D resumed their matchday 2 fixtures in the Champions League across Europe.
Lokomotiv Moscow were condemned to their second defeat in Group D as they lost to visiting Bundesliga side Schalke by 1-0.
Weston McKennie scored the winner two minutes from time courtesy of an assist from Ukrainian midfielder Yevheniy Konoplyanka.
In the other group fixture, Porto recorded their first victory in the Champions League with a lone goal from Moussa Marega to give the Portuguese side a 1-0 victory over the Turks.
Inter Milan joined Barcelona on top of the Group B standings after securing an away 2-1 win to Dutch champions PSV Eindhoven.
PSV drew first blood through Pablo Rosario but just before half time Radja Nainggolan equalized before Mauro Icardi scored the winner in the 66th minute.
It was a feast of goals at the Wembley Stadium as Barcelona handed a 4-2 defeat to Premier League side Tottenham.
Atletico Madrid and Borussia Dortmund continued their wining run in Group A following victories against FC Brugge and Monaco respectively.
The leadership of the group will be decided on matchday 3 when the Diego Simeone's side lock horns with Dortmund.
Liverpool were handed their first defeat away to Napoli with a Lorenzo Insigne's 90th minute winner.
In the other Group C tie, Neymar scored a hat-trick as PSG walloped Red Star Belgrade by 6-1 with Angel Di Maria, Edison Cavani and Kylian Mbappe getting on the scoresheet.
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